Trim14 autophagy
WebDue to impaired type I IFN production, Trim14-/- mice are highly susceptible to lethal HSV-1 infection. Taken together, our findings reveal a positive feedback loop of cGAS signaling generated by TRIM14-USP14 and provide insights into the crosstalk between autophagy … WebOct 6, 2016 · Due to impaired type I IFN production, Trim14-/-mice are highly susceptible to lethal HSV-1 infection. Taken together, our findings reveal a positive feedback loop of cGAS signaling generated by TRIM14-USP14 and provide insights into the crosstalk between …
Trim14 autophagy
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WebThe overexpression of MK-3903 reversed the inhibiting role of TRIM14 knockout on the proliferation and autophagy of SGC7901/5-FU cells. Conclusion TRIM14 promoted chemotherapy resistance of GC cells by regulating AMPK/mTOR pathway, and may be a … WebTRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation. Abstract. Close. Vote. Posted by 5 minutes ago. TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
WebMay 20, 2024 · TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses. Mol Cell. 2016 Oct 6;64(1):105-119. ... Chen M, Zhao Z, Meng Q, Liang P, Su Z, Wu Y, Huang J, Cui J. TRIM14 Promotes Noncanonical NF-κB Activation by Modulating p100/p52 Stability via Selective Autophagy. WebTRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses Author: Meixin Chen, Qingcai Meng, Yunfei Qin, Puping Liang, Peng Tan, Lian He, Yubin Zhou, Yongjun Chen, Junjiu Huang, Rong-Fu Wang, Jun …
WebAutophagy is your body’s cellular recycling system. It allows a cell to disassemble its junk parts and repurpose the salvageable bits and pieces into new, usable cell parts. A cell can discard the parts it doesn’t need. Autophagy is also quality control for your cells. Too … WebThe protein expressions of Trim14, LC3, and BECLIN1 were measured by western blotting. Results. TRIM14 was significantly upregulated in 5‐FU‐ and L‐OHP‐resistant GC tissues and cells. The overexpression of TRIM14 promoted the proliferation and autophagy of …
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WebHistone methylation regulates gene transcription through a variety of methylases and demethylases. The regulatory role of autophagy, an important process of protein degradation and recycling, in these histone modifiers is still unclear. We report that … the union myanmarWebFeb 1, 2024 · Abstract. Autophagy is a fundamental cellular process of protein degradation and recycling that regulates immune signaling pathways via multiple mechanisms. However, it remains unclear how autophagy epigenetically regulates the immune response. Here, … the union mlshttp://school.freekaoyan.com/gd/zsu/daoshi/2024/05-20/16214411511471914.shtml the union movementWebNov 3, 2024 · TRIM14 overexpression triggers the autophagy and chemotherapy resistance of GC cells . TRIM14 can stabilize dishevelled 2 (Dvl2), which causes resistance of glioma cells to temozolomide [ 10 ]. Dvl2 is a key upstream regulator for Wnt/β-catenin signaling … the union napoleon indianaWebMethods. CCK-8 assay, colony formation assay, Transwell assay, Western blot and quantitative real-time PCR (qRT-PCR) were performed to examine viability, proliferation, migration and invasion, genes and proteins’ level. To identify KCNQ1OT1 as a regulator of miR-125b-5p and miR-125b-5p as a regulator of CD147, we used miRNA target prediction … the union narrowsburg nyWebNov 2, 2024 · TRIM14 is a player in M. tuberculosis infection of macrophages Having previously described a crucial role for cGAS-dependent cytosolic DNA sensing in activating selective autophagy and type I IFN expression during M. tuberculosis infection (2), we the union nationsWebAutophagy is one of the three principal mechanisms used by cells to sequester, ... TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses. Mol Cell. … the union nevada city ca